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Title of the paper
Phytochemicals in Cancer- Pre clinical to clinical study
Title of the paper
Phytochemicals in Cancer- Pre clinical to clinical study
Amit S.
Choudhari1, Pallavi C. Mandave2, Manasi Deshpande3,
Prabhakar Ranjekar4*, Om Prakash5*
1.
Combi-Chem Bio-Resource Center, Organic
Chemistry Division, CSIR-National Chemical Laboratory, Pune, India
2.
Interactive Research School of Health Affairs, Bharati Vidyapeeth (Deemed
to be University), College of Ayurved, Pune , India
3.
Department of Dravyaguna Vigan [Ayurved Pharmacology], Bharati
Vidyapeeth (Deemed to be University), College of Ayurved, Pune , India
4.
Innovation Biologicals Pvt. Ltd., Pune, India
5.
Louisiana State University Health Sciences Center, Department of
Microbiology, Immunology and
Parasitology, and Stanley S. Scott Cancer Center, New Orleans, LA,
United States
* Correspondence: Manasi
Deshpande manasi08@gmail.com
ABSTRACT
Cancer is a
severe health problem that continues to be a leading cause of death worldwide.
Increasing knowledge of the molecular mechanisms underlying cancer progression
has led to the development of a vast number of anticancer drugs. However, the
use of chemically synthesized drugs has not significantly improved the overall
survival rate over the past few decades. As a result, new strategies and novel
chemoprevention agents are needed to complement current cancer therapies to
improve efficiency. Naturally occurring compounds from plants known as
phytochemicals, serve as vital resources for novel drugs and are also sources
for cancer therapy. Some typical examples include taxol analogs, vinca
alkaloids such as vincristine, vinblastine and podophyllotoxin analogs. These
phytochemicals often act via regulating molecular pathways which are implicated
in growth and progression of cancer. The specific mechanisms include increasing
antioxidant status, carcinogen inactivation, inhibiting proliferation,
induction of cell cycle arrest and apoptosis; and regulation of the immune
system. The primary objective of this review is to describe what we know to
date of the active compounds in the natural products, along with their
pharmacologic action and molecular or specific targets. Recent trends and gaps
in phytochemical based anticancer drug discovery are also explored. The authors
wish to expand the phytochemical research area not only for their scientific
soundness but also for their potential druggability. Hence, the emphasis is
given to information about anticancer phytochemicals which are evaluated at
preclinical and clinical level.
Keywordsh: Phytochemicals, Anticancer, Preclinical, Clinical,
Medicinal plants
